Hi,
I experianced the same problems named here, and even get the same results when downloading your savegame. Infact several posts in this section are all the same issue in my opinion, just slight variations from each other (explained below). The game ran fine until I started trying out custom content, maps, etc. This issue is horrible and utterly kills the game - and its very random too, read on;
1. Sometimes you can manage to get a single trip done, but when the train starts to load and the next stop, it freezes, while still burning money. Sometimes you dont even get a load when the train is first bought!
2. Sometimes mail and passengers aren't affected, sometimes they are
3. Sometimes the train doesnt even arrive at the correct place of a station to unload/load - causing it to stop completely, while the game says its moving at anywhere between 1 and 10 kpm (very random) This effect is very similiar to a 'waiting' train - as if it was waiting on something to move.
4. When loading at a station (on both first and second loads) the carriages dont actually appear - only the train.
5. Occurs on both a single direct track between two stops and with added tracks, or any combination of, eg. slips, splits, etc.
6. Doesnt matter what map you play, what train you use, track or track path, industry, era, objective, number of AI, difficulty or routing level - it happens at random, regardless.
My computer specs are fully capable of running this game, the system itself has almost nothing extra running in the background - im pretty sure graphics/sound/antivirus are all that runs besides the normal Windows processes. The game is patched to v1.10, was freshly installed god knows how many times to find whats wrong(!), all set to default settings.
Though, tried I enabling logging in 'Settings.ini' and everything runs no problem. Now im enjoying that great basin and range map

Try it out and see if the problems remain (Link below)
http://www.hookedgamers.com/wiki/Sid_Me ... :Interface